Endocrine Abstracts

Hashimoto disease, a chronic autoimmune lymphocytic thyroiditis, is the most common cause of hypothyroidism with a prevalence of 10–12% in the general population. Literature data suggests that persistently high levels of oxidative are considered as relevant risk factor in the occurrence and development of autoimmune diseases, including Hashimoto. The DNA and RNA are particularly valuable to the oxidative damage, and guanine is the most prone base to oxidation. Thus, the D...

Angioinvasion in papillary thyroid cancer (PTC) is a crucial determinant of patient prognosis. 3-Nitrotyrosine (3-NT) is a byproduct resulting from the interaction between nitric oxide and tyrosine, serving as a discernible marker indicative of oxidative stress. Within the context of PTC, oxidative stress plays a pivotal role in carcinogenic processes, particularly concerning angioinvasion. Patients with elevated levels of oxidative stress are correlated with an unfavorable cl...

Recently, 59 percent of European adults was diagnosed with obesity or overweight according to the 2022 Regional Obesity Report presented by the World Health Organization (WHO). Thus, insight into factors implicated in overweight and obesity may have important therapeutic implications. Interestingly, increased cortisol secretion and psychosocial stress have been demonstrated to be related with body weight-dependent insulin resistance and beta cells failure. Thus, the study was ...

Adult growth hormone deficiency (GHD) is widely acknowledged for its association with heightened mortality, primarily linked to an increased risk of cardiovascular complications. Endothelin-1 (ET-1) is implicated in various cardiovascular conditions, including hypertension, atherosclerosis, and heart failure, where imbalances in its levels or signaling have been identified. Despite the distinct primary functions of growth hormone and endothelin within the body, both hormones a...